Author：Weitzel, T.;Dittrich, S.;Lopez, J.;Phuklia, W.;Martinez-Valdebenito, C.;Velasquez, K.;Blacksell, S. D.;Paris, D. H.;Abarca, K.
Address：From Clinica Alemana de Santiago, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo (T.W.), Veterinary Hospital Puente Alto (J.L.), and Departamento de Enfermedades Infecciosas e Inmunologia Pediatrica (C.M.-V., K.A.) and Millennium Institute on Immunology and Immunotherapy (K.A.), Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, and Hospital de Ancud, Ancud (K.V.) - all in Chile; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos (S.
Article Type：Journal Article
Journal：N Engl J Med
Scrub typhus is a life-threatening zoonosis caused by Orientia tsutsugamushi
organisms that are transmitted by the larvae of trombiculid mites. Endemic scrub
typhus was originally thought to be confined to the so called "tsutsugamushi
triangle" within the Asia-Pacific region. In 2006, however, two individual cases
were detected in the Middle East and South America, which suggested that the
pathogen was present farther afield. Here, we report three autochthonous cases
of scrub typhus caused by O. tsutsugamushi acquired on Chiloe Island in southern
Chile, which suggests the existence of an endemic focus in South America.
(Funded by the Chilean Comision Nacional de Investigacion Cientifica y
Tecnologica and the Wellcome Trust.).